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Apigenin
Chamomile extract
Overview
A bioflavonoid found in chamomile. Popularised by Andrew Huberman but backed by limited direct human trials as a standalone supplement.
How it works
Binds weakly and selectively to benzodiazepine receptors in the brain, producing a mild anxiolytic and sedative effect without the dependence profile of benzodiazepines.
Benefits
Sedation: mild sedative effect via benzodiazepine receptors.
C
Dosage
50 mg before bed
Safety Profile
Contraindications
- Pregnancy
- Blood thinner medications (theoretical interaction)
Research Summary
Popularised by Huberman. Limited human trials of the isolated compound. Chamomile tea itself has better (though still modest) evidence.
Sources
Last updated: 2026-04-10
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Medical Disclaimer
This is a research summary, not medical advice. Body Signals is an independent research digest — it summarises published research for informational purposes and is not a healthcare provider. Supplements like melatonin, valerian, and magnesium can interact with prescription medications — check with your doctor or pharmacist before starting any supplement. Chronic insomnia may indicate an underlying condition (sleep apnoea, thyroid dysfunction, depression) and warrants a medical evaluation.
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